Published results of a randomized international study involving 1,702 patients aged 3-59 months with severe pneumonia showed that treatment regimens with the use of parenteral penicillin and oral doses of amoxicillin did not differ in effectiveness.

Amoxicillin for oral administration is the drug of choice for initial treatment of children with purulent bronchitis, pneumonia, otitis, sinusitis, and urinary tract infections. Its efficiency was confirmed by the results of many randomized placebo-controlled studies.

According to the American Academy of Pediatrics, in the absence of risk factors the treatment with amoxicillin is effective in approximately 80% of children with acute bacterial sinusitis. These risk factors include: recent (less than 90 days) antimicrobial therapy, and age younger than 2 years. Use of amoxicillin as first-line therapy is possible due to its effectiveness, safety, good tolerability as well as low cost.

source